Grand Panacea

The Grand Panacea is the mysterious substance which Ronny Schiatto bestows upon the Advena Avis ' passengers in 1711. It grants those who ingest it complete immortality, regardless of the amount consumed.

The Grand Panacea's formula is a secret known only to Maiza Avaro, as he was the one to summon Ronny on the Advena Avis. Though a majority vote was cast in favor of Maiza keeping such knowledge to himself, he nonetheless shared half of his knowledge with his brother Gretto before changing his mind.

Outraged by the outcome of the vote, and driven by greed, the alchemist Szilard Quates would devour Gretto and twelve other alchemists before leaping overboard and into the sea. With Gretto's knowledge serving as a head start, Szilard's subsequent research into the Grand Panacea still took over two hundred years before finally coming to fruition in November 1930 with the completion of the Cure-All Elixir – functionally the same as the Grand Panacea, but slightly different in composition.

Pre-1711 Recipients (c. 1400s/1500s)

 * Dalton Strauss
 * Renee Paramedes Branvillier
 * Archangelo
 * Seven other alchemists†

1711 Recipients (Advena Avis)

 * Begg Garott
 * Czeslaw Meyer
 * Denkurō Tōgō
 * Elmer C. Albatross
 * Gretto Avaro†
 * Huey Laforet
 * Lebreau Fermet Viralesque
 * Maiza Avaro
 * Nile
 * Sylvie Lumiere
 * Szilard Quates†
 * Victor Talbot
 * Zank Rowan†
 * Unnamed alchemist devoured by Ennis in New York†
 * Pierre (as named in the anime)†
 * Italo (as named in the anime)†
 * Fourteen other alchemists†

1711 Recipients (Others)

 * Lucrezia de Dormentaire (she drank half of Huey's portion, which he sent to her)
 * Niki (Lucrezia gave her some of Elmer's portion)
 * Avaro Sr. (Lucrezia gave him some of Elmer's portion)

Trivia

 * Dalton claims that he first heard of the 'wine of immortality' from the sage Majeedah Batutah, a practically legendary figure among alchemists. As she is purportedly still alive in the 1700s, master to Nile, Denkurō, and Zank, it is possible that she is not only another recipient of the Grand Panacea, but the oldest immortal of human origin in existence.