Grand Panacea

The Grand Panacea is the mysterious substance which Ronny Schiatto bestows upon the Advena Avis ' passengers in 1711. It grants those who ingest it complete immortality, regardless of the amount consumed.

The Grand Panacea's formula is a secret known only to Maiza Avaro, as he was the one to summon Ronny on the Advena Avis. Though a majority vote was cast in favor of Maiza keeping such knowledge to himself, he nonetheless shared half of his knowledge with his brother Gretto before changing his mind.

Outraged by the outcome of the vote, and driven by greed, the alchemist Szilard Quates would devour Gretto and twelve other alchemists before leaping overboard and into the sea. With Gretto's knowledge serving as a head start, Szilard's subsequent research into the Grand Panacea still took over two hundred years before finally coming to fruition in November 1930 with the completion of the Cure-All Elixir – functionally the same as the Grand Panacea, but slightly different in composition.

Effects
The Grand Panacea gifts whoever drinks it the ability to rapidly heal any injury or illness including restoring amputated limbs. If drunk the recipient will stop aging however, they will remain fertile and female immortals can undergo full pregnancies.

There are restrictions however, the Grand Panacea takes the current form of whoever drinks in their correct state and will keep the body in that condition even if they are injured or ill. In 1932 however, Elmer states he has heard the Panacea 'has a mind of it's own and naturally improves things over time' though it may take a very long time considering the extent of individual's ailments. This unpredictability also lends explanation to how female immortals can remain eternally fertile and become pregnant.

If an individual loses a limb it will not regrow, instead the limb cannot be destroyed and will recreate itself then attempt to return to the body.

Whilst recipients of the Grand Panacea cannot die by conventional means they can die by killing one another. This can only be done by placing their right hand on another immortals head and thinking 'I want to eat'. If this is done the immortal will dissolve into the other immortal granting all the first immortal their memories as if they were their own.

A condition upon drinking the Grand Panacea is that immortals must always use their true names when speaking face to face. They are in fact physically unable to use false names.

The children of immortals do not inherit immortality.

Pre-1711 Recipients (c. 1400s/1500s)

 * Dalton Strauss
 * Renee Parmedes Branvillier
 * Archangelo
 * Seven other alchemists†

1711 Recipients (Advena Avis)

 * Begg Garott
 * Czeslaw Meyer
 * Denkurō Tōgō
 * Elmer C. Albatross
 * Gretto Avaro†
 * Huey Laforet
 * Lebreau Fermet Viralesque
 * Maiza Avaro
 * Nile
 * Sylvie Lumiere
 * Szilard Quates†
 * Victor Talbot
 * Zank Rowan†
 * Unnamed alchemist devoured by Ennis in New York†
 * Pierre (as named in the anime)†
 * Italo (as named in the anime)†
 * Fourteen other alchemists†

1711 Recipients (Others)

 * Lucrezia de Dormentaire (she drank half of Huey's portion, which he sent to her)
 * Niki (Lucrezia gave her some of Elmer's portion)
 * Avaro Sr. (Lucrezia gave him some of Elmer's portion)

Trivia

 * Dalton claims that he first heard of the 'wine of immortality' from the sage Majeedah Batutah, a practically legendary figure among alchemists. As she is purportedly still alive in the 1700s, master to Nile, Denkurō, and Zank, it is possible that she is not only another recipient of the Grand Panacea, but the oldest immortal of human origin in existence.